Pressor mechanism of vincristine sulfate.
نویسندگان
چکیده
Studying the pharmacological activities of vincristine sulfate (VCR), one of the alkaloids isolated from Vinca rosea Linn. by Svoboda et al. (1), Anderson et al. (2) observed the pressor, positive chronotropic and re spiratory stimulating effects in dogs. Since no action mechanisms of these pharmacological effects were reported, the authors attempted to clarify its pressor mechanisms. Pressor effect of VCR (0.1-1.0 mg/kg, i.v.) was observed in dogs, cats, rabbits, guinea-pigs and rats under pentobarbital or urethane anesthesia. Fig. 1 shows the pressor effects of VCR in cats. The carotid blood pressure increased during first 60 minutes after the administration, and then gradually returned to normal. In cats, dogs, rabbits and guinea-pigs, VCR was characteristic of slow and long lasting pressor substance. On the contrary, pressor effect in rats was temporal lasting about 10 minutes. Pressor effect of VCR was abolished in the vagotomized spinal cats (Fig. 1), and was slightly potentiated by the intra-carotid arterial administration. Pretreatment of an a-adrenergic blocker, dibenamine (2 mg/ kg, ix.), which reversed the pressor effect of epinephrine, markedly inhibited the pressor effect of VCR. The pressor effect of VCR was also completely abolished by the reserpine pretreated on the previous day (1.5 mg/kg, s.c.), while the pressor effect of tyramine was depressed to one half by the same treatment. No effects were observed on the spontaneous movements of guinea-pig isolated atrium and rabbit isolated intestine by the administration of VCR into the organ bath (Magnus method). Increases of perfusate was
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عنوان ژورنال:
- Japanese journal of pharmacology
دوره 19 2 شماره
صفحات -
تاریخ انتشار 1969